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KMID : 1140120120170040288
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Cancer Prevention Research
2012 Volume.17 No. 4 p.288 ~ p.294
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Expression Analysis of BI-1 Family Genes in Diverse Breast Cancer Cell Lines
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Han Ji-Hae
Kim Jung-Hyun
Yang Gwang-Mo
Cho Ssang-Goo
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Abstract
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The anti-apoptotic protein, Bax inhibitor-1 (BI-1), is evolutionarily conserved from bacteria to humans and is up-regulated in several cancer cells. Here, we analyzed the amino acid sequences of the BI-1 family proteins (BI-1, FAIM2, TMBIM1, TMBIM4, GRINA, and GHITM) and compared their expression patterns in normal breast cell (MCF10A) and several breast cancer cell lines (T-47D, MCF7, MDA-MB231, MDA-MB468, and SK-BR3). Moreover, through Oncomine database-based analysis, we could find that their expression patterns were similar to those of patient samples. Taken together, our data suggest that expression of BI-1 among the BI-1 family genes may be most intimately associated with breast cancer.
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KEYWORD
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Apoptosis, Bax inhibitor-1 (Bi-1) family proteins, Breast cancer
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